The influence of selenium on immune responses – Hoffmann P.R & Berry M.J. 2008

Selenium (Se) is a potent nutritional antioxidant that carries out biological effects through its incorporation into selenoproteins. Given the crucial roles that selenoproteins play in regulating reactive oxygen species (ROS) and redox status in nearly all tissues, it is not surprising that dietary Se strongly influences inflammation and immune responses.

Results: Overall, there is considerable evidence strengthening the notion that selenium affects different types of immune responses in different ways. The influence of selenium-supplementation on enhancing immunity depends on what type of antigens and tissues are involved. Much of the available evidence suggests that boosting selenium levels in moderately low selenium individuals may have more immune enhancing effects than supplementing a selenium adequate individual.

Reference

S.  P. R. Hoffmann, M. J. Berry, Mol Nutr Food Res, 2008, 52, 1273-1280. The influence of selenium on immune responses.