Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment – Lee et al. 2013
Epidemiological studies have suggested a beneficial effect of fish oil supplementation in halting the initial progression of Alzheimer’s disease. A study in 2013 found that the active DHA-rich oil in Active Memory significantly improved memory function including short term and working memory, immediate verbal memory and delayed recall memory.
Potential role of dietary n−3 fatty acids in the prevention of dementia and macular degeneration – Johnson EJ, Schaefer EJ. 2006
Dementia and age-related macular degeneration (AMD) are major causes of disability in the elderly. n−3 Fatty acids, particularly docosahexaenoic acid (DHA), are highly concentrated in brain and retinal tissue and may prevent or delay the progression of dementia and age-related macular degeneration. Low dietary intakes and plasma concentrations have been reported to be associated with dementia, cognitive decline, and age-related macular degeneration risk.
Effects of a high-DHA multi-nutrient supplement and exercise on mobility and cognition in older women – Fairburn, 2019
No treatment effects were observed for the primary outcome, habitual walking speed. Improvements in verbal memory and executive function were seen for all treatments groups v.placebo (all, P < 0·05). Significant improvements in self-reported emotional well-being were seen with multi-nutrient and exercise groups v. placebo (P = 0·03). The results suggest that the high-DHA multi-nutrient supplement produces similar improvements in cognitive function to aerobic exercise, offering the intriguing prospect that supplementation may be able to mitigate some of the effects of low physical activity on cognitive function in the elderly.
A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility – Strike SC, Carlisle A, Gibson EL, Dyall SC, 2016
Significant improvements were seen in 2 of the 4 cognitive tests, with shorter mean latencies in a motor screening task (p < .05) & more words remembered (p < .03), and 1 of the 3 primary mobility measures with improved habitual walking speed (p < .05). Compared with the placebo, supplementation also produced significantly higher blood DHA levels (p < .02). This pilot study, showed that Active Memory improved cognition and mobility in able older females at clinically relevant levels, suggesting a potential role in reducing the decline to frailty.
Effect of Omega-3 Multinutrient supplement on memory in older adults – Garcia-Escrivà et al. 2014
Prospective, randomised trial with an unsupplemented control group. This study which was the first one to use Active Memory showed improvements were greater in the Efamol Active Memory treated patients for 5 of the memory tests with the results being significantly greater for delayed prompted text recall. There was no or less deterioration in the Efamol Active Memory treated patients for 5 of the EQ 5D tests with the results for anxiety and depression being significantly less.
