Vitamins and Minerals for Energy, Fatigue and Cognition – Tardy et al. 2020
There is a strong biological and physiological rationale that indicates that the long-known involvement of vitamins and minerals in cellular energy production translates into functional and physiological outcomes in humans, including perceived physical and mental fatigue as well as psychological and cognitive functions.
Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia – Pouteau et al. 2018
Animal and clinical studies suggest complementary effects of magnesium and high-dose pyridoxine (vitamin B6) on stress reduction. Magnesium plays an essential physiological role in the body as an enzymatic cofactor in over 600 biochemical reactions. Low serum magnesium concentrations increase the release of stress-associated and affect their access to the brain.
Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment – Lee et al. 2013
Epidemiological studies have suggested a beneficial effect of fish oil supplementation in halting the initial progression of Alzheimer’s disease. A study in 2013 found that the active DHA-rich oil in Active Memory significantly improved memory function including short term and working memory, immediate verbal memory and delayed recall memory.
Potential role of dietary n−3 fatty acids in the prevention of dementia and macular degeneration – Johnson EJ, Schaefer EJ. 2006
Dementia and age-related macular degeneration (AMD) are major causes of disability in the elderly. n−3 Fatty acids, particularly docosahexaenoic acid (DHA), are highly concentrated in brain and retinal tissue and may prevent or delay the progression of dementia and age-related macular degeneration. Low dietary intakes and plasma concentrations have been reported to be associated with dementia, cognitive decline, and age-related macular degeneration risk.
Comparisons between autism spectrum disorders and anxiety disorders – Ooi et al. 2014
Participants showed significant improvements on all subscales of the Social Responsiveness Scale (P<0.01) and the Social and Attention Problems syndrome scales of the Child Behaviour Checklist (P<0.05). Blood fatty acid levels were significantly correlated with changes in the core symptoms of ASD.
The role of polyunsaturated fatty acids in the management of Egyptian children with autism – Meguid et al. 2008
20 of the 30 autistic children had clinically significant improvements in autistic behaviours (CARS)- improved concentration, eye contact, language development and motor skills. Blood DHA and AA increased with treatment from sub-normal levels
EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviours – Dr. Stevens & Burgess, 2003
After treatment with Efalex there were significant improvements in ADHD symptoms including a 73% reduction in hyperactivity, 64% improvement in attention, 69% improvement in conduct and a 79% improvement in opposition defiant disorder.
The effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children – Richardson AJ, Puri BK. 2002
The Beechlawn Study was the first double-blind, placebo controlled trial to be published in a peer reviewed journal. It showed Efalex could reduce a number of ADHD related symptoms including cognitive problems, anxiety and hyperactivity. After 12 weeks mean scores for cognitive problems and general behaviour problems were significantly lower for the group treated with HUFA than for the placebo group
Effects of a high-DHA multi-nutrient supplement and exercise on mobility and cognition in older women – Fairburn, 2019
No treatment effects were observed for the primary outcome, habitual walking speed. Improvements in verbal memory and executive function were seen for all treatments groups v.placebo (all, P < 0·05). Significant improvements in self-reported emotional well-being were seen with multi-nutrient and exercise groups v. placebo (P = 0·03). The results suggest that the high-DHA multi-nutrient supplement produces similar improvements in cognitive function to aerobic exercise, offering the intriguing prospect that supplementation may be able to mitigate some of the effects of low physical activity on cognitive function in the elderly.
A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility – Strike SC, Carlisle A, Gibson EL, Dyall SC, 2016
Significant improvements were seen in 2 of the 4 cognitive tests, with shorter mean latencies in a motor screening task (p < .05) & more words remembered (p < .03), and 1 of the 3 primary mobility measures with improved habitual walking speed (p < .05). Compared with the placebo, supplementation also produced significantly higher blood DHA levels (p < .02). This pilot study, showed that Active Memory improved cognition and mobility in able older females at clinically relevant levels, suggesting a potential role in reducing the decline to frailty.
